THE INFLUENCE OF HORMONAL STATUS ON SKIN CHRONOAGING PROCESSES: PATHOPHYSIOLOGICAL ASPECTS AND PREDICTIVE DIAGNOSTICS

Abstract

This paper presents a theoretical and practical analysis of the influence of
hormonal status on skin chronoaging processes. The study is based on an integrative approach
combining endocrinological assessment (estradiol, TSH, T4, prolactin) with high-frequency
ultrasound sonography (33 MHz and 75 MHz). Systemic hormonal imbalance is shown to
be a key predictor of dermal matrix degradation. The efficacy of a combined protocol
comprising microneedle RF lifting, thulium laser, and topical resveratrol therapy is
substantiated. The developed algorithm for personalized correction ensures a high degree of
treatment targeting, allowing involutional processes to be slowed and structural skin integrity
to be restored. These findings open new prospects for predictive anti-aging medicine and for
optimizing dermatocosmetology protocols based on evidence-based instrumental diagnostics.