THE ROLE OF MOLECULAR-GENETIC PREDICTORS IN THE DEVELOPMENT OF RECURRENT BRONCHIAL OBSTRUCTION IN CHILDREN

Abstract

The aim of our work was to analyze the association of polymorphic loci
rs1042714 (Gln27Glu) of the ?2-adrenoreceptor (ADRB2) gene in children of the Uzbek
population with recurrent bronchial obstruction(RBO). The material for the study was
patients with RBO of Uzbek ethnicity aged from 1 to 15 years. The comparison group
included children with acute obstructive bronchitis(AOB), bronchial asthma (BA), and
practically healthy children of the same age and population. In the molecular genetic study,
a diagnostic kit was used to detect polymorphisms in human genes by polymerase chain
reaction. In the molecular genetic study, a diagnostic kit was used to detect polymorphisms
in human genes by polymerase chain reaction. The results of the obtained studies showed
that children who possess polymorphic variants of Gln27Glu of the ADRB2 gene of the G/
G mutational genotype are predisposed to the development of recurrent bronchial obstruction
in children. Analysis of the prevalence of Gln27Glu polymorphic variants of the ADRB2
gene in patients with RBO showed that the owners of the G/G mutational genotype have
a high risk of predisposition to the development of the disease.